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Heart Failure with Mid-Range Ejection Fraction (HFmrEF) who falls in the intermediate range, often with an LVEF between 40 and 49%

10.1021/jm201497k J

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Indeed, it seems that the isomerization activity is catalyzed by a heme-free enzyme, whereas heme-bound mPGES-2s can degrade PGH 2 into hydroxyl heptadecatrienoic acid and malondialdehyde, instead of converting it to PGE 2 (Jania et al., 2009