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Western blot analysis of LC3II, a surrogate marker for autophagy 32 , revealed autophagic induction in GSH-depleted cells

SARS CoV-1 enhances the expression of TGF-1, leading to elevated ROS, depletion of glutathione, and decreased levels of the substrates and enzymes required for glutathione synthesis

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Szczesny B, Mdis K, Yanagi K et al (2014) AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro