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Growth hormone secretagogues, including sermorelin, require baseline IGF-1 measurement and oncology history screening before prescribing

These typically normalize as the body adapts

For the primary efficacy analysis of actimetry and home diary outcomes, the outcome values were calculated using the measures performed during the planned weeks of assessment (the first and last week of each treatment period) without deviations from the target oral l-dopa dose (that is, a week when the patient did not receive the oral optimized l-dopa dose determined in phase 1 of the DIVE-1 study)

Rasmussen et al., 2016

it was abandoned, almost certainly because no sponsor was willing to underwrite the next phase