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Although CA IX catalytic activity is key to these processes, PG-like domain can also act via a non-catalytic mechanism, in which it serves as an antenna enhancing export of protons coupled with facilitated export of lactate ions through monocarboxylate transporters [32]

DSIP functions through mechanisms that are not fully characterized but appear to involve modulation of sleep-wake regulatory centers in the brain and interactions with various neurotransmitter systems
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