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H 2 S, for example, can bind to protein metal centres, such as haem moieties in mitochondrial cytochrome c oxidase or haemoglobin (reviewed e.g

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimers disease
was additionally supported by the Biotechnology and Biological Sciences Research Council (BLAST Pump-Priming Award, Grant No: BB/W01825X/1)

It is often a signal from the body that something deeper needs attention

Bagot RC, Tse YC, Nguyen H-B, Wong AS, Meaney MJ, Wong TP
