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Inotropic modulations of multicellular preparations typically manifest within 1020 min at higher exogenous doses (100300 M), while lower doses (130 M) require relatively longer exposure durations ranging from 30 to 120 min (Inoue and Pappano, 1983

doi: 10.1016/s0168-8278(00)80166-x

10.1592/phco.27.9.1237 199 ShalataA.EderyM.HabibC.GeniziJ.MahroumM.KhalailyL.et al

The marked increases in protein levels of BNIP3, P62, and PARKIN were clearly observed in the tibialis anterior muscle of mice with castration (112), and the increased ratio of LC3 II/LC3 I in mice with hypogonadism, which indicates a strong association between androgen deficiency and enhancement of mitophagy (113)