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Both peroxyl radicals and alkoxyl radicals are further cyclized and dependent on the type of polyunsaturated fatty acid, degraded into reactive aldehydes such as 4-hydroxynonenal (4-HNE) or malondialdehyde (MDA) (Fig
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In the mouse model of bleomycin-induced lung fibrosis, Gpx3 levels in tissue and BALF were increased in the inflammatory (day 37) and fibrotic (day 1428) phase 35,46 , but had returned to baseline after resolution of fibrosis at day 56
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