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Deficient IGF- 1 input to vascular endothelial cells leads to impaired vasodilation, microvascular rarefaction, and reduced muscle endurance, without significant muscle atrophy
it decreases to 70% for the second stage, 58% for stage III, and fewer than 15% for stage IV (128)
Adv Enzymol Relat Subj Biochem 1956;17: 65-134
