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Moreover, oxidative stress can also influence the expression of proteins involved in iron metabolism, creating a feedback loop that accelerates cell death under the combined pressures of oxidative stress and iron metabolism imbalance (58)

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While it is gratifying that after 12 months of treatment with curcumin, the tolerance was good and there was no significant difference in the incidence of adverse events compared to the placebo group, indicating the safety of long-term use of curcumin