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Before starting B12 supplements , particularly high-dose formulations, discuss with your GP if you have: A history of sleep disorders Existing anxiety or mood disorders Cardiovascular conditions Kidney disease (which may affect B12 metabolism and test interpretation) Leber's hereditary optic neuropathy (cyanocobalamin is contraindicated
On average, 420,303 tests cost $4.4 million per year
Diminishing results despite consistent dosing is another signal
