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It has been reported that there is no reduction in its secretion in patients with T2DM [13] but a nearly total loss of insulinotropic effect is observed, even at supraphysiological concentrations, implying the existence of GIP resistance [14]

In addition, the use of GM technology may encounter regulatory challenges and market acceptance issues, thereby a comprehensive assessment of safety and ethics is required

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Diagnosis of B12 deficiency is complicated by the fact that levels of B12 in the blood are maintained even when stores are low at the expense of tissue levels

Hong J, Jia Y, Pan S, Jia L, Li H, Han Z, Cai D, Zhao R