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Moreover, exercise stimulates the release of angiogenic myokines via the muscle-brain axis, including IL-6, irisin, and follistatin-like 1 (FSTL1), upregulating VEGF and membrane-type I matrix metalloproteinase (MT1-MMP) to facilitate endothelial cell migration and lumen formation [281]

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One possibility related to the ACore-associated normalization of spine size is structural stabilization leading to reduced spine turnover, which could be assessed via repeated imaging of the same spines over hours to days