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IGF-1 is the major regulator of growth and controls bone elongation by promoting chondrocyte proliferation and hypertrophy [2,3]

It regulates deiodinase enzymes responsible for thyroid hormone conversion, affects both the secretion and production of TSH, and participates in hormone synthesis via the modulation of transcription factors [85]

Cohen et al., 1995, 1997

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13.5 Balancing safety with clinical benefit Among the primary safety concerns associated with probiotic administration are opportunistic infections, as immunocompromised individuals face a significantly increased risk of systemic infections originating from probiotic strains