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doi: 10.1056/NEJMc2007575 121

Symptoms can include diarrhea, a metallic taste in the mouth, nausea, brittle nails, hair loss, coughing and more

In sarcoidosis patients, IFN- may exert anti-apoptotic effects on macrophages by inducing the expression of the cyclin-dependent kinase inhibitor p21/Waf1, thereby contributing to the persistence of lung inflammation [122]

Such an imbalance is responsible for severe damage to essential biomolecules, such as lipids (lipid peroxidation), proteins (oxidation and inactivation), and DNA (strand breakage and mutations), which is associated with the pathogenesis of numerous diseases, including cancer, neurodegenerative diseases, cardiovascular diseases, and the aging process [28]

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