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As a family of tyrosine kinase inhibitors, CDK4/6 inhibitors (CDK4/6i) reduce phosphorylation of Rb protein and preclude cell cycle progression (Shikanai et al

Additionally, the NF-B signaling pathway is activated in response to oxidative stress, regulating cellular proliferation and apoptosis in inflammatory states

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4 Analysis of important natural compounds Since pharmacotherapy based on a single target has been insufficient for drug development in complex diseases, the emerging multi-target approach is a promising strategy for the search of new drug candidates