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Located at key interfaces, including the BBB, meninges, and perivascular spaces, mast cells are uniquely positioned to detect environmental stressors and rapidly respond by releasing a potent cocktail of mediators such as histamine, tryptase, cytokines, and prostaglandins

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We acknowledge support from INSERM (S.G.), the Stanford Medical Scientist Training Program (A.M.), the National Science Foundation (A.C.K.), National Institutes of Health grants NS028471 (B.K.K.) and DA031418 (B.K.K.), and from the Mathers Foundation (B.K.K

In aged mice testes, FOXO4 was predominantly expressed in cytoplasm and showed nuclear localization in some Leydig cells (arrows)

Even in high doses, your body can only absorb a fraction of B12 supplements