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Collectively, the advances summarized above for the different hallmarks of aging highlight the importance of understanding the molecular mechanisms by which each hallmark influences aging pathologies and, more importantly, the functional interconnections between different hallmarks

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5,10-MTHF reductase (5,10-MTHFR) carries out a central reaction in folate metabolism with the production of 5-MTHF, which is required for the biosynthesis of methionine, purine nucleotides, and thymidylate [17]

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