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S., Goodnow, C

This curve helps determine: Minimum Effective Dose (MED): The lowest dose that produces a statistically significant effect

Intraperitoneal administration with the autophagy-inducing drug cysteamine reduced cigarette smoke-induced aggresome formation in the lungs, inflammatory responses in bronchoalveolar lavage fluid (BALF), and emphysematous changes in mice

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Similarly, tiragolumab (anti-TIGIT), which can remodel the immunosuppressive TME and favor a memory-like CD8 + T-cell phenotype, has shown enhanced efficacy when combined with atezolizumab [342]