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In rodent models, intrarenal injection of syn preformed fibrils induced renal deposits and triggered propagation of pathology to the CNS

Sections were immersed in a buffer containing terminal deoxynucleotidyl transferase and digoxigenin-labelled nucleotides for 2 h at 37 C

These signals produced during cell death allow the recruitment and activation of immune cells, such as macrophages, regulatory T cell, and neutrophils (Matsushita et al., 2015

Aging-related decline of glutathione peroxidase 3 and risk of cardiovascular events in patients with atrial fibrillation