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Stem Cell Signaling Promotes regenerative capacity

The mechanism of sustained amylin receptor stimulation could theoretically exacerbate underlying pancreatic vulnerability

doi: 10.3389/fphar.2025.1587314 Received 04 March 2025 Accepted 21 April 2025 Published 28 April 2025 Volume 16 - 2025 Edited by Ramzi Mothana, King Saud University, Saudi Arabia Reviewed by Jovana Rajkovic, University of Belgrade, Serbia Sidharth Mehan, Indo-Soviet Friendship College of Pharmacy, India Updates Copyright 2025 Jiang, Lhamo, Ma, Ye, Chen, He, Xu and Huang

We showed that RSPO2-deficient mice have reduced active -catenin signalling and a decreased mineral deposition rate and osteoblast number, similar to the phenotype observed with the knockout of LRP5/6