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Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), people following vegan or strict vegetarian diets (as B12 is naturally found almost exclusively in animal products), individuals with pernicious anaemia or other malabsorption conditions, those taking certain medications such as metformin or proton pump inhibitors long-term, and people with significant nitrous oxide exposure (including recreational use), which can inactivate B12 in the body

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This is the most common route for B12 in a clinic, usually into the deltoid muscle of the upper arm

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This suggests that SIRT7 may be a potential target for therapeutic intervention aimed at preserving cognitive function in the elderly 102

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A prospective study on folate, B12, and pyridoxal 5'-phosphate (B6) and breast cancer

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This irregularity can complicate ovulation and reduce chances of conception

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