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For instance, p53 transcriptionally upregulates spermidine/spermine N1-acetyltransferase 1 (SAT1), driving polyamine metabolism, a process associated with increased arachidonate 15-lipoxygenase (ALOX15) activity, collectively fostering lipid hydroperoxide generation (106)

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This is certainly an interesting new area of research in that it suggests yet another plausible mechanism by which a steady diet of red meat or L-carnitine supplements may speed up the development of coronary artery disease, notes Dr