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In two of the cases, hypocalcemia appears to have been caused by the administration of Na2EDTA (disodium EDTA) and in the third case the type of EDTA was unknown
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10.3389/fonc.2023.1089115 122

The covalent CDK7 inhibitor THZ1 was found to be highly effective against SCLC in a combination in vivo / in vitro study by suppressing the expression of proto-oncogenes such as c-Myc , SRY-box transcription factor 2 ( SOX2 ), and nuclear factor I B (NFIB)

These results may explain, in part, the finding that low-dose dietary zinc supplementation extended the lifespan of SOD1 G39A transgenic mice (Ermilova et al., 2005), as this mutation is known to reduce Sod1s affinity for zinc (Crow et al., 1997)
