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GGT is a membrane-bound enzyme facing the extracellular compartment

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Interestingly, ferrylHb-mediated responses are dependent on the activation of nuclear factor kappaB (NF-B), requires actin polymerization, involves the activation of the c-Jun N-terminal kinase and the p38 mitogen-activated protein kinase signal transduction pathways but not dependent on TLR4 activation (33)

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A cellular defense memory imprinted by early life toxic stress