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Description
"Linus Pauling's Childhood (19011910)"
10.1016/j.cell.2019.01.021 40
Through structural modification, structureactivity relationships could be inferred that the dihydrothiophene ring and methoxyl groups at C-16 and C-17 had a key role in the cytotoxicity of 181 , while the hydroxyl groups at C-1, C-11 and C-13 reduced the activity
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PMID: 9065401
