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As electrons pass through the ETC complexes, protons are pumped from the mitochondrial matrix into the intermembrane space (IMS), creating a transmembrane electrical potential that is used to drive ATP production by ATP synthase (Complex V)

and BRIGELIUS-FLOH, R

A major extracellular enzyme, GPX3, is also found in the cytoplasm and plasma membranes of the mammalian kidney, epididymis, heart, lung, liver, brain, adipose tissue, mammary gland, and gastrointestinal tract (Nirgude and Choudhary, 2021)

Even if it is still unclear whether OS is a primary or a secondary cause of neurodegeneration in ALS, overwhelming evidence indicates the pathological role of OS, and alterations in KEAP1 and NRF2 expression and in KEAP1-NRF2 activity may explain the progressive MN degeneration and death associated with ALS [170]

rushing the process or doubling doses won't speed up improvement