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These findings support Ayahuasca-derived alkaloids as candidates for further investigation in neuroprotection and substance use disorder treatment.

Here, we evaluated the combined inhibition of the glutathione and thioredoxin antioxidant systems in preclinical models of pancreatic ductal adenocarcinoma, using buthionine sulfoximine (BSO) that targets glutathione synthesis, and auranofin that targets thioredoxin recycling

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