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neoformans has part of the genetic elements that control sulfur assimilation, the regulatory network may be different from other fungi

Knockout of LPCAT3 markedly reduces the proportion of membrane PUFA-PLs and significantly decreases cellular sensitivity to GPX4 inhibitors (38)
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Neurotoxicology 32, 215226

Therefore, targeting the NRF2 pathway is an important strategy for treating male infertility
