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Fei Gao: Conceptualization, Methodology, Writing - review & editing, Supervision, Funding acquisition

The importance of omega-3 polyunsaturated fatty acids in the maintenance of physical health is well known, as they are involved in a variety of physiological functions related to neurogenesis, neurotransmission, and neuroinflammation, and play essential roles in brain development, activity, and aging (91)

This mechanism allows for the generation of the lipidated version of LC3 via the incorporation of the ATG5-ATG12 E3 ubiquitin ligase [119]

Over time, these deposits cause localized retinal atrophy and photoreceptor dysfunction, leading to gradual central scotomas and the need for brighter light during detailed tasks