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Importantly, a long-standing debate around the biological relevance of the immunoactive synthetic fragment MDP remains unclear due to a lack of NAM-based probes

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Supplementary material The Supplementary Material for this article can be found online at: References 1 AlshehriO

J Invest Dermatol 130:27819 Shen G, Xu C, Hu R (2006) Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

This approach is particularly beneficial in trials involving multiple treatment arms or stratified subgroups, where conventional fixed designs often prove too rigid or inefficient