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Compared with normal neutrophils, GLUT1 expression and glycolysis are both elevated in tumor-associated neutrophils from a mouse model of lung adenocarcinoma

The proliferative advantages of high ROS levels and reduced risk of apoptosis are maintained by the activation of redox-dependent transcription factors in tumor cells [3]

These results suggest that USP10 partially promotes autophagy in PDAC cells through PLK1

In addition, activated Akt can relinquish the inhibition of mammalian target of rapamycin (mTOR) signaling pathways and promote proteins synthesis (Fig

doi:10.1016/S1474-4422(15)70016-5 Heo JM, Ordureau A, Paulo JA, Rinehart J, Harper JW (2015) The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN/NDP52 recruitment and TBK1 activation to promote mitophagy