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This is at least in part due to its adverse effects on the body's stores of vitamins and enzymes and the oxidative defense system

Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, Brown LM, Valenzuela CA, Wolpaw AJ, Stockwell BR

Hepatology 48 , 12241231 (2008)

Free radicals are unstable molecules that can damage your cells

This reduced output means skin loses structural support progressively, with wrinkles forming where the weakened matrix can no longer maintain smooth surface topology
