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doi: 10.1016/j.cca.2017.02.016 26 LiBXuYPangDZhaoQZhangLLiMet al

In the ischemia/reperfusion-induced fibrosis C57BL/6J mouse model, transcriptomic and metabolomic analyses showed that dapagliflozin treatment mitigated accumulation of tricarboxylic acid (TCA) circulating metabolites and up-regulation of inflammation in fibrotic renal cortical tissue

pathogenesis, diagnosis, and therapy

Moreover, NK cells transfected with small interfering RNA (siRNA) against PRF1 showed dramatic decreases in PRF1 expression, coupled with downregulated NK cell cytotoxicity (data not shown), suggesting that perforin is an essential factor for determining NK cell killing capacity

Prof Med J 28(09):13221325 Malla D et al (2021) Prevalence of vitamin B12 deficiency in patients with type II diabetes mellitus on metformin