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Lack of differential abundances of 1 or 2 components of a pathway does not mean that the pathway itself is not altered between 2 groups of participants
However, as described earlier, the significance of this putative Na + -binding site for MurJ function or structure could not be determined because mutations altering most of the coordination sphere residues led to significant or complete loss of expression, suggesting that the Na + -binding site might serve a structural role

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