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This is one reason it is often discussed in anti-aging and regenerative applications

Low expression of claudin-4 is associated with poor prognosis in esophageal squamous cell carcinoma

Unlike necrosis, paraptosis maintains membrane integrity

[DOI] [PMC free article] [PubMed] [Google Scholar] Scherlie R

This connection is particularly evident in neurological conditions like HIV-associated neurocognitive disorders (HAND), where mtDNA dysfunction is implicated in pathogenesis
