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Severe liver disease can include inflammation of the liver (chronic active hepatitis), inflammation of the bile ducts (primary sclerosing cholangitis), which narrow and eventually close, and replacement of functional liver tissue with scar tissue (cirrhosis)

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87 A metaanalysis including 20 published articles describing the frequency of the e4 form among people in the United States who had been diagnosed with Alzheimer's dementia found that 56% had one copy of the APOEe4 gene, and 11% had two copies of the APOEe4 gene