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Gray hair and hair showing signs of discoloration start to appear, and they could spread quickly

Short-chain fatty acids (SCFAs), as key gut metabolites, have various effects on host health and disease (Koh et al., 2016

Folate supplementation counteracts these effects by inhibiting NF-B activation, which dramatically lowers the levels of inflammatory cytokines such as IL-6 and TNF-, thereby reducing liver inflammation (Sid et al., 2018)

Phase I reactions include oxidation, reduction and hydrolysis

A study (Houtman et al., 2019) shows that BECN1 deficiency enhances IL-1 and IL-18 release from microglia, causing aberrant neuroinflammation and neurodegeneration, potentially linked to high mobility group box 1 (HMGB1) secretion