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For people who need meaningful weight reduction, tirzepatide is the far more effective compound by a large margin

Psychiatr Genet (2009) 19:1716 10.1097/YPG.0b013e32832cebd2 [DOI] [PubMed] [Google Scholar] 80.Pasca SP, Dronca E, Kaucsar T, Craciun EC, Endreffy E, Ferencz BK, et al

Even though mortality had not decreased, this was linked to a 27% decrease in the risk of cardiovascular events [89]

The authors interpreted the data as supporting NNMT inhibition as a candidate exercise-mimetic

While generally considered safe, use during pregnancy and breastfeeding should be discussed with a doctor
