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ATP7A-LINKED NEURODEGENERATIVE DISORDERS Unlike AT7B, where mutations in the gene result in a single known clinical phenotype (Wilson disease), mutations in ATP7A cause three X-linked neurodegenerative diseasesMenkes disease, occipital horn syndrome (OHS), and X-linked distal hereditary neuropathy (dHMN) (Kaler, 2011)

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4 Discussion Following the trends and perspectives of the toxicity testing in the 21st Century vision ( in vivo -like exposure to pulmonary toxicants (Xiong et al., 2021)

Elkin PL, Mullin S, Sakilay S

Heavy metals in biological samples of cancer patients: A systematic literature review