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The standard treatment is intravenous (IV) administration of recombinant FVIII protein, which is complicated by formation of neutralizing anti-FVIII antibodies in more than 30% of patients with severe disease [139, 140]

Against this background, this review provides an overview of the structure and function of the bloodbrain barrier and discusses the abnormal changes in the BBB in different CNS diseases

* Correspondence: Lidan Yang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers