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They dont have lung disease, but it is recognized that with repeated bouts of EIPH over time, there can be inflammatory changes that may ultimately lead to permanent changes in the architecture of the lungs, particularly around the veins. While this development constitutes a pathologic condition, researchers are convinced that at its outset, EIPH is not a primary pathologic problem

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15 Claudin-2 expression increased colonocyte proliferation and provided protection against colitis-induced colonocyte death in a phosphatidylinositol-4,5-bisphosphate 3 kinase/Bcl-2-dependent manner

FACS confirmed that the results are consistent with the observation (Figure 3C)