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Since vascular growth is not only up-regulated but also accompanied by significant changes in their architecture (i.e., abnormal vasculature, disorganization, etc.) and function [129,130], a tumor burdened with those vessels may eventually be resistant to various therapeutic methods, including systemic treatment in the form of chemotherapy or radiotherapy [131]

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As pointed out by Matheny et al[89]., it is not clear whether MGF is present in vivo and its role in SC activation should be ascertained by generating knockout mouse models

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