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In 2017 alone, CVDs claimed the lives of approximately 17.8 million individuals, accounting for 31% of the global mortality rate (WHO CVD Risk Chart Working Group, 2019)

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Moreover, Sun et al.'s study highlighted CoQ10's role in activating the Nrf2/Keap1/ARE pathway, consequently improving mitophagy and reducing damage to the kidneys in diabetic nephropathy [89]

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First, while antibiotic suppression is used to invoke a role for gut microbiota in the generation of the metabolite(s) monitored, antibiotics can also have direct effects on the host, altering normal metabolism (57, 58)