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Description
Since hippocampal atrophy is a hallmark of major depression, compounds that protect and potentially restore hippocampal tissue address a fundamental aspect of the disease process

Section 5.2.3.4 provides further details

The extent of damage to astrocytes in the cerebral cortex and hippocampus (CA1, CA3, DG) was observed

Dupont J, Holzenberger M

Sources Sikiric P, Hahm KB, Blagaic AB, et al
