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Over time, this sustained immune activation results in chronic inflammation, which not only contributes to tissue damage but also fuels viral proliferation by providing a continuous supply of target cells, resulting in the gradual depletion of CD4+ T cells, hallmarking HIV progression

doi: 10.3748/wjg.v11.i23.3570

For example, under conditions of OGD, the local concentration of lactate increases, which triggers astrocyte responses by upregulating N-Myc downstream-regulated gene 2 (NDRG2) to alleviate the inflammatory state [136]

L-theanine: a potential multifaceted natural bioactive amide as health supplement
[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Villalon-Garcia I., Povea-Cabello S., Alvarez-Cordoba M., Talaveron-Rey M., Suarez-Rivero J.M., Suarez-Carrillo A., Munuera-Cabeza M., Reche-Lopez D., Cilleros-Holgado P., Pinero-Perez R., et al
