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It often causes a catching sensation in the knee

In March 2025 it will be a year since the Nice Guideline on B12 Deficiency in over 16s was published

10.1016/j.cmet.2017.01.006 Cell Metab

Re-ingestion allows for absorption of nutrients made available by bacterial fermentation, and also of vitamins and other nutrients synthesized by the gut bacteria, including vitamin B 12

The lever that reliably backfires is impatience: compressing the ladder to chase a number trades the one tolerability tool the protocol has for a burst of avoidable GI symptoms
