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To be an efficient antioxidant, flavonoid molecules should fulfill two criteria: (i) flavonoid molecules, present at low concentration with respect to the substrate to be oxidized, should prevent or delay free radical-mediated oxidation

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NOS uncoupling (e.g., tetrahydrobiopterin depletion) flips NOS from NO to O 2 production, amplifying ROSRNS feed-forward loops (Kuzkaya et al

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Then, the homogenate was centrifuged at 3000 rpm for 10 min at 4 C