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Furthermore, reductions in insulin concentration were significantly larger in the LC group than in the CT group (LC vs

10.1371/journal.pone.0288523 83 JiangR.DuX.LnnerdalB
In the absence of AMPK activity, cells exhibit elevated mtROS levels and undergo premature senescence [175]

this barrier may be overcome by leveraging exosome-enriched plasma mitochondrial DNA (mtDNA) with a 70% increase in sensitivity or salivary metabolomics, where lactate and glucose levels correlate strongly with CSF measurements ( r = 0.81) [49]
