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Because of structural similarities, AM404 is a weak agonist of cannabinoid receptors type 1 and 2 (CB1 and CB2), and an inhibitor of the anandamide membrane transporter (AMT), which leads to increased levels of endogenous cannabinoids (2729)

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However, based on the research to date, researchers will want to consider the following guidelines when when administering these peptides: Subcutaneous and intramuscular injections are considered more effective due to enhanced bioavailability , but using BPC-157 + TB-500 nasal spray could have certain advantages depending on the therapeutic objective and study design