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2 10 The unsaturated acyl chains in membrane phospholipids and cholesterol in membranes, among biomolecules, are highly susceptible to pathologic free radical damage for the following reasons 16 : First, the inherent structure of polyunsaturated fatty acid chains (polyunsaturated acyl chains are normally unconjugated, and the alpha-methylenic carbons between carbons with double bonds have allylic hydrogen that can readily enter into free radical reaction

This approach could reduce unwanted side effects and enhance therapeutic efficacy (151, 152)

Front Neurosci , 12 , 845

These are not just theoretical benefits

7 (Elsevier, 2017)